Searchable abstracts of presentations at key conferences in endocrinology

ea0050oc6.5 | Bone, Calcium and Neoplasia | SFEBES2017

Tumor immunosuppressive environment and tamoxifen resistance in rats exposed to EE2 in utero can be prevented with HDAC and DNMT inhibitors

Bouker Kerrie , Andrade Fabia De Oliveira , Hil Leena

Maternal exposures during pregnancy to endocrine disrupting chemicals increase daughter’s breast cancer risk in humans and animal models. We have previously found that these exposures also pre-program offspring’s mammary tumors to exhibit increased resistance to antiestrogen therapy, and that treatment with valproic acid (HDAC inhibitor) and hydralazine (DNMT inhibitor) prevented antiestrogen resistance. Here we investigated if maternal exposure to ethinyl estradiol ...

ea0050oc6.5 | Bone, Calcium and Neoplasia | SFEBES2017

Tumor immunosuppressive environment and tamoxifen resistance in rats exposed to EE2 in utero can be prevented with HDAC and DNMT inhibitors

Bouker Kerrie , Andrade Fabia De Oliveira , Hil Leena

Maternal exposures during pregnancy to endocrine disrupting chemicals increase daughter’s breast cancer risk in humans and animal models. We have previously found that these exposures also pre-program offspring’s mammary tumors to exhibit increased resistance to antiestrogen therapy, and that treatment with valproic acid (HDAC inhibitor) and hydralazine (DNMT inhibitor) prevented antiestrogen resistance. Here we investigated if maternal exposure to ethinyl estradiol ...